Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCC9 (O60706) - Overview - Molecular Target Synopsis

Protein


ABCC9, ATP-binding cassette sub-family C member 9
UniProt O60706

Also Known as ABCC9_HUMAN, ABCC9, SUR2

Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Interacts with KCNJ11.

Isoforms / Transcripts (Protein Coding)


Drugs


ABCC9 is targeted by Approved Drugs Pinacidil, Minoxidil. (see details)
Pinacidil
Minoxidil

Sub-cellular localization


UniProt: ABCC9 is active in the following subcellular-locations: membrane.
GO terms: ABCC9 is active in the following subcellular-locations: inward rectifying potassium channel, membrane, plasma membrane, sarcolemma, sarcomere.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCC9 has gain in 19 cell-lines, loss in 4 cell-lines and no signal in 982 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, MCF7, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, G140, C2BBe1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: GM12878, SK-N-SH, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to ABCC9 there are:
17 structures (59 chains) solved
15 are solved in complex with at least one small molecule ligand
5 are solved with an approved drug

ABCC9 is solved in complex with the approved drug(s):

GBM/GLYBURIDE (5YKE_B, 5YKE_D, 5YKE_F, 5YKE_H, 5YKF_B, 5YKF_D, 5YKF_F, 5YKF_H, 5YKG_B, 5YKG_D, 5YKG_F, 5YKG_H, 5YW7_B, 6BAA_E, 6BAA_F, 6BAA_G, 6BAA_H).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCC9 has been screened with 475 compounds (1129 bioactivities), 160 compounds have bioactivities that show binding affinity of <= 500nM (264 bioactivities). (see details)