Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRMT3 (O60678) - Overview - Molecular Target Synopsis

Protein


PRMT3, Protein arginine N-methyltransferase 3
Enzyme Classification 2.1.1.-
UniProt O60678

Also Known as ANM3_HUMAN, PRMT3, HRMT1L3

Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. Monomer or homodimer (By similarity). Interacts with EPB41L3; this inhibits methylation of target proteins. Interacts with the 40S ribosomal protein RPS2.

4RYL
HUMAN PROTEIN ARGININE METHYLTRANSFERASE 3 IN COMPLEX WITH 1- ISOQUINOLIN-6-YL-3-[2-OXO-2-(PYRROLIDIN-1-YL)ETHYL]UREA
RCSB/PDB
Inspect Structure
See all 3D Structures for PRMT3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PRMT3 is active in the following subcellular-locations: cytoplasm.
GO terms: PRMT3 is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PRMT3 has gain in 2 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, SW_620, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KYSE-70, Hs 746T, KYSE-150

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, NHLF, A549

(see details)

3D Structures


For PRMT3 there are:
5 structures (5 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PRMT3 has been screened with 80 compounds (89 bioactivities), 6 compounds have bioactivities that show binding affinity of <= 500nM (7 bioactivities). (see details)