Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC16A7 (O60669) - Overview - Molecular Target Synopsis

Protein


SLC16A7, Monocarboxylate transporter 2
UniProt O60669

Also Known as MOT2_HUMAN, SLC16A7, MCT2

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter. Interacts with GRID2IP.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC16A7 is active in the following subcellular-locations: cell membrane.
GO terms: SLC16A7 is active in the following subcellular-locations: integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC16A7 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SN12C, HL_60, SF_539

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H596, SU-DHL-1, VMRC-LCD

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HFDPC, BJ

(see details)


Screening and Chemistry


SLC16A7 has been screened with 9 compounds (10 bioactivities). (see details)