Molecular Target Synopsis
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GMDS (O60547) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed32
Chains with at least one site assessed as druggable using the strict criteria32
Chains with at least one site assessed as druggable using the relaxed criteria32


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5IN4_B GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 72.5 50.4 Yes Yes
2 empty 2.43 65.1 29.4 No No
3 empty 2.25 63.8 17.7 No No
4 empty 2.47 64.4 21 No No
5 bound 2.04 69.7 16.4 No No
6 empty 2.08 67.2 14.2 No No
7 empty 2.68 60.5 15.2 No No
8 empty 2.43 54.8 17.7 No No
9 empty 2.3 67.7 11.8 No No
10 empty 1.71 62.2 12.2 No No
6Q94_D GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 77.7 35.2 Yes Yes
2 empty 2.23 56.7 18 No No
3 empty 2.48 61.9 19.7 No No
4 empty 1.93 60.4 15.2 No No
5 empty 2.37 68.9 12.2 No No
6 empty 2.2 55.2 14.9 No No
7 empty 2.07 63.9 13.6 No No
8 empty 2.48 61 12.4 No No
9 empty 1.87 49.3 11.6 No No
10 empty 2.01 60.1 10.2 No No
6GPK_B GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 73.9 41.6 Yes Yes
2 bound 2.1 61.8 31.8 No No
3 bound 2.28 66.7 14.7 No No
4 empty 2.02 67.9 13 No No
5 empty 2.49 65.6 17.1 No No
6 empty 2.17 66.9 13.7 No No
7 empty 2.1 62.1 14.6 No No
8 empty 2.29 71.7 12.7 No No
9 empty 2.51 66.9 10.5 No No
10 empty 2.5 65.7 11.1 No No
1T2A_C GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 71.1 45.2 Yes Yes
2 empty 2.39 64.4 29.5 No No
3 empty 2.26 65.3 15.3 No No
4 empty 2.43 63.8 20.6 No No
5 empty 2.39 67.3 8.1 No No
6 empty 2.34 62.2 14.3 No No
7 empty 2.8 59.1 15.9 No No
8 empty 2.45 66.3 9.6 No No
9 empty 2.59 64.7 8.1 No No
10 empty 2.29 74.5 9.4 No No
6GPL_D GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 78.8 34 Yes Yes
2 bound 1.74 60.2 18.3 No No
3 empty 1.91 58.9 14.3 No No
4 empty 2.19 57.8 15.4 No No
5 empty 2.15 57 13.3 No No
6 empty 2.27 56.3 14 No No
7 empty 2.34 65.9 9.2 No No
8 empty 2 60.4 12.4 No No
9 empty 2.37 54.7 10.8 No No
10 empty 2.02 46.7 10.2 No No
6GPJ_A GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 78.6 34.6 Yes Yes
2 empty 2.16 62.5 30.9 No No
3 bound 2.01 60.2 21.1 No No
4 empty 2.18 56.4 12.8 No No
5 empty 2.26 65 11.9 No No
6 empty 2.32 66.4 13.1 No No
7 empty 2.27 50.9 14.5 No No
8 empty 1.99 60.1 12.1 No No
9 empty 2.31 63.4 9.2 No No
10 empty 2.09 62.6 9.9 No No
5IN4_D GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 76 35.9 Yes Yes
2 empty 2.36 61.4 36.2 No No
3 empty 2.45 61.4 33.5 No No
4 empty 2.1 63.6 17.7 No No
5 empty 2.27 69.1 16.2 No No
6 bound 2.04 68.4 16.6 No No
7 empty 2.31 64.6 18 No No
8 empty 2.36 70.3 8.4 No No
9 empty 1.8 59.1 10 No No
10 empty 2.28 72.1 11.3 No No
1T2A_A GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 69.6 49.7 Yes Yes
2 empty 2.38 65.5 27 No No
3 empty 2.32 63.5 22.7 No No
4 empty 2.11 65.1 15.1 No No
5 empty 2.31 73.6 16 No No
6 empty 2.57 62 16.9 No No
7 empty 2.35 63 15.7 No No
8 empty 1.79 69.7 11.5 No No
9 empty 2.23 73.4 9.7 No No
10 empty 2.47 74.3 7.7 No No
6GPL_B GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 92.3 21.6 Yes Yes
2 bound 1.83 56.3 19.5 No No
3 bound 2.19 63 29.7 No No
4 empty 1.98 61.1 15.5 No No
5 bound 2.34 52.9 18.4 No No
6 empty 2.35 55.5 15.1 No No
7 empty 2 56 13.8 No No
8 empty 2.35 64.4 12.7 No No
9 empty 1.93 57.7 13.5 No No
10 empty 2.17 51.6 12.5 No No
6Q94_C GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 72.8 38.2 Yes Yes
2 empty 2.43 64.4 31.6 No No
3 empty 2.18 68.5 17.6 No No
4 empty 2.28 68.9 16.1 No No
5 empty 2.12 68.4 13.1 No No
6 empty 2.44 66.2 16.2 No No
7 empty 2.46 63.7 12.8 No No
8 empty 2.3 75.5 8.1 No No
9 empty 1.98 65.1 11.8 No No
10 empty 2.1 62 8 No No
6GPJ_B GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 74.9 35.9 Yes Yes
2 empty 2.31 60 19.5 No No
3 empty 1.81 63.3 17.6 No No
4 bound 1.87 61.7 14.8 No No
5 empty 2.17 52.9 19.4 No No
6 bound 2.27 66.7 12.1 No No
7 empty 2.23 58.3 12.6 No No
8 empty 2.11 60.6 11.5 No No
9 empty 2.4 53.6 11.2 No No
10 empty 2.39 58.9 9 No No
5IN5_A GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 71.4 48.9 Yes Yes
2 empty 2.39 61.9 30.3 No No
3 empty 2.55 66.8 21 No No
4 empty 2.41 60.1 19.5 No No
5 bound 2.09 67.1 17.7 No No
6 empty 2.09 69.5 14.6 No No
7 empty 2.11 62.2 16.1 No No
8 empty 2.52 64.9 12.7 No No
9 bound 2.4 73.5 7.4 No No
10 empty 1.67 66.2 10.6 No No
6GPL_E GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 74.9 42.6 Yes Yes
2 empty 1.97 64.6 29.3 No No
3 empty 2.1 67 14.7 No No
4 empty 2.36 62.2 20.1 No No
5 empty 2.27 59.6 15.7 No No
6 empty 2.2 61.2 15.7 No No
7 empty 2.35 66.2 11.8 No No
8 empty 2.32 64.2 10.8 No No
9 empty 2.25 71.7 13.5 No No
10 empty 2.08 59.2 12.9 No No
6Q94_H GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 87.5 22 Yes Yes
2 empty 1.97 53 21.9 No No
3 empty 2.18 63.1 26.3 No No
4 bound 2.1 60.4 24.4 No No
5 bound 1.97 98.1 0 Yes No
6 empty 2.32 68.1 15.2 No No
7 empty 2.34 60.7 12.4 No No
8 empty 1.86 62.2 11.3 No No
9 empty 2.13 60.3 11.7 No No
10 empty 2.23 52.3 15 No No
5IN4_C GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 71.1 45.9 Yes Yes
2 empty 2.25 62.3 30 No No
3 empty 2.38 62 19 No No
4 empty 2.45 66.4 20.8 No No
5 empty 2.31 69.3 13.4 No No
6 bound 1.85 70.6 9.8 No No
7 empty 2.57 61.5 12.8 No No
8 empty 2.27 65.5 10.8 No No
9 empty 2.28 65.5 20.1 No No
10 empty 2.66 75.3 9.1 No No
6GPK_C GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 91.3 21.6 Yes Yes
2 empty 1.79 57.2 19.3 No No
3 bound 1.69 61.9 19.9 No No
4 empty 2.34 66 12.5 No No
5 empty 2.27 60.2 14.7 No No
6 empty 2.21 60.3 13.6 No No
7 empty 2.19 54.5 12.8 No No
8 empty 2.18 51.1 13.3 No No
9 empty 2.22 58.7 12.3 No No
10 empty 1.88 66.2 9.5 No No
6Q94_F GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 70.5 42 Yes Yes
2 empty 2.35 64.8 31.7 No No
3 empty 2.26 66.7 19.6 No No
4 empty 2.41 67.2 16.2 No No
5 empty 2.3 68.2 17.6 No No
6 empty 2.56 67.4 23.3 No No
7 empty 2.18 66.7 12.9 No No
8 empty 2.72 62.4 13.4 No No
9 empty 2.78 73.2 9.3 No No
10 empty 2.63 64.3 12.2 No No
6GPK_A GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 92.2 24.8 Yes Yes
2 empty 1.95 53.8 22.2 No No
3 bound 2.26 62.7 30.3 No No
4 empty 2.38 66.8 15.9 No No
5 empty 1.97 61.5 16.2 No No
6 empty 2.21 60.1 13.1 No No
7 empty 2.14 51.9 13.1 No No
8 empty 2.11 53.6 16 No No
9 empty 2.05 58.3 11.7 No No
10 empty 2.31 59.8 12.8 No No
5IN4_A GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 73.8 40 Yes Yes
2 empty 2.39 60.2 37.7 No No
3 empty 2.23 64.5 21.6 No No
4 empty 2.43 62.1 18.4 No No
5 empty 2.7 61.4 19.3 No No
6 bound 2.08 69.2 17.4 No No
7 empty 2.1 68.2 13.9 No No
8 empty 2.23 62.7 9.5 No No
9 empty 2.07 57.9 18.4 No No
10 empty 2.35 74.6 11.4 No No
6Q94_G GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 73.4 39.3 Yes Yes
2 empty 2.29 63 30 No No
3 empty 2.21 64.2 25.6 No No
4 bound 2.36 73.2 14.8 No No
5 empty 2.37 65.8 16.4 No No
6 empty 2.2 66.5 16.6 No No
7 empty 1.63 64.9 10.8 No No
8 empty 2.7 61.2 16.8 No No
9 empty 2.27 74 7.2 No No
10 empty 2.27 67.1 9.1 No No
5IN5_D GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 75.9 39.3 Yes Yes
2 empty 2.24 63.8 31.3 No No
3 empty 2.52 67.7 15.3 No No
4 empty 2.3 62.9 19.6 No No
5 empty 2.63 62.5 21.5 No No
6 empty 2.06 70.2 15.1 No No
7 empty 2.43 64 16.9 No No
8 bound 1.81 70.7 16.3 No No
9 empty 2.15 55.9 18.6 No No
10 empty 2.17 59.8 16.6 No No
6GPK_D GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 74 40.7 Yes Yes
2 bound 2.39 60 31.1 No No
3 empty 2.21 62.9 19 No No
4 empty 2.56 61.6 20.3 No No
5 empty 2.41 67.6 15 No No
6 empty 2.44 68.2 12.2 No No
7 empty 2.02 67.3 13.5 No No
8 empty 2.13 68.1 11.5 No No
9 empty 1.71 64.2 9.1 No No
10 empty 2.59 65.2 13.8 No No
6GPJ_C GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 72.5 41.7 Yes Yes
2 empty 2.36 64.3 29.5 No No
3 empty 2.42 64.2 19.1 No No
4 empty 2.2 71.3 10.7 No No
5 empty 2.26 71.7 10.7 No No
6 empty 2.18 59.8 16.4 No No
7 empty 2.38 68.1 10.3 No No
8 empty 2.35 68.6 13.7 No No
9 empty 2.25 73.6 9.5 No No
10 empty 2.23 59.6 13.3 No No
1T2A_D GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 73.2 42.5 Yes Yes
2 empty 1.91 64.7 31 No No
3 empty 2.35 63.2 19.8 No No
4 empty 2.35 72.8 14.2 No No
5 empty 2.41 64.2 18 No No
6 empty 2.21 67.2 14.7 No No
7 empty 2.12 63.6 12.4 No No
8 empty 2.58 62.1 11.2 No No
9 empty 2.27 78.3 7.4 No No
10 empty 2.86 60.7 10.7 No No
6GPJ_D GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 75 36.8 Yes Yes
2 bound 2.34 62.1 30.8 No No
3 empty 2.2 61.8 25.8 No No
4 empty 2.43 62.9 18.1 No No
5 empty 2.37 62.5 19.5 No No
6 empty 2.24 66.6 16.4 No No
7 empty 2.34 69.8 9.2 No No
8 empty 2.2 68.4 14.7 No No
9 empty 2.69 67.7 10.7 No No
10 empty 2.54 57 14.4 No No
5IN5_B GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 73 39.7 Yes Yes
2 empty 2.4 60.9 30.3 No No
3 empty 2.44 61.9 22.4 No No
4 empty 2.32 65.6 17.2 No No
5 empty 2.74 62 18.3 No No
6 empty 2.08 65.6 15.4 No No
7 empty 2.08 64.3 14.3 No No
8 bound 1.68 67 11.1 No No
9 empty 2.26 66.3 8.8 No No
10 empty 2.37 60.7 11.3 No No
6Q94_E GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 74.6 48.8 Yes Yes
2 empty 2.4 61.2 31.5 No No
3 empty 2.39 59.7 23.8 No No
4 empty 2.22 68.1 19.9 No No
5 empty 2.18 67.5 17.9 No No
6 empty 2.69 62.7 23.7 No No
7 empty 2.4 69.1 15.1 No No
8 empty 2.09 69.3 15.6 No No
9 empty 2.35 70.6 7.7 No No
10 empty 2.04 78.7 10.1 No No
6GPL_C GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 73.3 39.1 Yes Yes
2 bound 1.96 63.1 29 No No
3 empty 2.27 64.3 16.6 No No
4 empty 2.53 62.9 19.2 No No
5 empty 2.14 68.3 14.7 No No
6 empty 2.39 65.8 13.5 No No
7 empty 2.13 59.9 17.3 No No
8 empty 1.88 61.5 15.9 No No
9 empty 2.28 74.3 7.8 No No
10 empty 2.56 66.1 9.5 No No
1T2A_B GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 73.7 39.2 Yes Yes
2 empty 2.33 65 27.3 No No
3 empty 2.47 67.6 19.3 No No
4 empty 2.35 64 34.8 No No
5 empty 2.29 59.2 17.1 No No
6 empty 2.38 68.5 14.3 No No
7 empty 2.17 64 15.5 No No
8 empty 2.71 63.6 17.1 No No
9 empty 2.47 61.2 10.8 No No
10 empty 2.22 68.9 6.8 No No
6Q94_A GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 72.3 43.7 Yes Yes
2 empty 2.32 65.7 29.2 No No
3 empty 2.24 70.3 19.8 No No
4 empty 2.31 64.7 23.9 No No
5 empty 2.51 69.1 15.8 No No
6 empty 2.67 61.1 22.1 No No
7 empty 2.42 69.5 16.3 No No
8 empty 2.39 67 17.2 No No
9 empty 1.88 64.2 9.5 No No
10 empty 2.32 73.9 7.6 No No
5IN5_C GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 71.2 54.2 Yes Yes
2 empty 2.29 62.6 36.9 No No
3 empty 2.44 66.9 19.9 No No
4 empty 2.38 62.6 22.9 No No
5 empty 2.22 69.9 12 No No
6 bound 1.78 67 9.8 No No
7 empty 2.54 68.5 7.6 No No
8 empty 2.59 64.5 13.5 No No
9 empty 2.33 70.8 9.6 No No
10 empty 1.82 62.6 9.5 No No
6Q94_B GDP-mannose 4,6 dehydratase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 73.7 37.7 Yes Yes
2 empty 2.45 63.4 32.9 No No
3 empty 2.53 67.7 21.1 No No
4 empty 2.24 63.6 21.9 No No
5 empty 2.66 62.7 20.8 No No
6 empty 2.39 66.5 19.2 No No
7 empty 2.38 57.1 16 No No
8 empty 1.96 64.6 14 No No
9 empty 2.41 68.8 10.1 No No
10 empty 2.24 74.2 9.8 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed5
Domains assessed as druggable using the strict criteria5
Domains assessed as druggable using the relaxed criteria5

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1T2A_A (99078) GDP-mannose 4,6 dehydratase NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.8Å Yes Yes
1T2A_B (99079) GDP-mannose 4,6 dehydratase NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.8Å Yes Yes
1T2A_C (99080) GDP-mannose 4,6 dehydratase NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.8Å Yes Yes
1T2A_A (4094846) GDP-mannose 4,6 dehydratase NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.8Å Yes Yes
1T2A_B (4094846) GDP-mannose 4,6 dehydratase NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.8Å Yes Yes
1T2A_D (4094846) GDP-mannose 4,6 dehydratase NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.8Å Yes Yes
1T2A_C (4094846) GDP-mannose 4,6 dehydratase NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.8Å Yes Yes
1T2A_D (99081) GDP-mannose 4,6 dehydratase NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.8Å Yes Yes
Ligand-based Druggability Score: 0
Ligand-based Druggability Score Percentile: 80%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


GMDS is involved in 1 interactions in the network.


Druggability
Overall Druggability Percentile: 25.42
Druggability for Cancer Therapeutics: 35.10
Druggability for Other Therapeutics: 24.11
Cancer-Associated
Cancer-associated percentile : 12.97
Network Articulation Point
Is GMDS critical for communication in the network?


Detailed Graph Legend:Help