Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

GMDS (O60547) - Overview - Molecular Target Synopsis


GMDS, GDP-mannose 4,6 dehydratase
Enzyme Classification
UniProt O60547

Also Known as GMDS_HUMAN, GMDS

Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

GO terms: GMDS is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project GMDS has gain in 3 cell-lines, loss in 6 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: COLO205, SW_620, RPMI_8226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-719, MKN-45, HM7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, SK-N-SH

(see details)

3D Structures

For GMDS there are:
7 structures (32 chains) solved
7 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis