Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GMDS (O60547) - Overview - Molecular Target Synopsis

Protein


GMDS, GDP-mannose 4,6 dehydratase
Enzyme Classification 4.2.1.47
UniProt O60547

Also Known as GMDS_HUMAN, GMDS

Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.

6Q94
CRYSTAL STRUCTURE OF HUMAN GDP-D-MANNOSE 4,6-DEHYDRATASE (S156D) IN COMPLEX WITH GDP-MAN
RCSB/PDB
Inspect Structure
See all 3D Structures for GMDS

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
372ENSG00000112699ENST00000380815ENSP00000370194O60547-1
342ENSG00000112699ENST00000530927ENSP00000436726O60547-2

Sub-cellular localization


GO terms: GMDS is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GMDS has gain in 3 cell-lines, loss in 6 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, SW_620, RPMI_8226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-719, MKN-45, HM7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, SK-N-SH

(see details)

3D Structures


For GMDS there are:
7 structures (32 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis