Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADCY9 (O60503) - Overview - Molecular Target Synopsis

Protein


ADCY9, Adenylate cyclase type 9
Enzyme Classification 4.6.1.1
UniProt O60503

Also Known as ADCY9_HUMAN, ADCY9, KIAA0520

Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ADCY9 is active in the following subcellular-locations: cell membrane.
GO terms: ADCY9 is active in the following subcellular-locations: axon, dendrite, integral component of membrane, integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADCY9 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A498, HS578T, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 255.T, Hs 675.T, OVMANA

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, BJ, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to ADCY9 there are:
3 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ADCY9 has been screened with 51 compounds (56 bioactivities), 23 compounds have bioactivities that show binding affinity of <= 500nM (24 bioactivities). (see details)