Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSL4 (O60488) - Overview - Molecular Target Synopsis

Protein


ACSL4, Long-chain-fatty-acid--CoA ligase 4
Enzyme Classification 6.2.1.3
UniProt O60488

Also Known as ACSL4_HUMAN, ACSL4, ACS4, FACL4, LACS4

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSL4 is active in the following subcellular-locations: endoplasmic reticulum membrane, microsome membrane, mitochondrion outer membrane, peroxisome membrane.
GO terms: ACSL4 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum membrane, extracellular exosome, integral component of membrane, lipid droplet, membrane, mitochondria-associated endoplasmic reticulum membrane, mitochondrial outer membrane, neuronal cell body, peroxisomal membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSL4 has gain in 0 cell-lines, loss in 32 cell-lines and no signal in 972 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_MB_231, SF_539, A498

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 675.T, Hs 746T, LCLC-103H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, HSMM

(see details)


Screening and Chemistry


ACSL4 has been screened with compounds ( bioactivities). (see details)