Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ACSL4 (O60488) - Overview - Molecular Target Synopsis


ACSL4, Long-chain-fatty-acid--CoA ligase 4
Enzyme Classification
UniProt O60488

Also Known as ACSL4_HUMAN, ACSL4, ACS4, FACL4, LACS4

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: ACSL4 is active in the following subcellular-locations: endoplasmic reticulum membrane, microsome membrane, mitochondrion outer membrane, peroxisome membrane.
GO terms: ACSL4 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum membrane, extracellular exosome, integral component of membrane, lipid droplet, membrane, mitochondria-associated endoplasmic reticulum membrane, mitochondrial outer membrane, neuronal cell body, peroxisomal membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ACSL4 has gain in 0 cell-lines, loss in 32 cell-lines and no signal in 972 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MDA_MB_231, SF_539, A498

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 675.T, Hs 746T, LCLC-103H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, HSMM

(see details)

Screening and Chemistry

ACSL4 has been screened with compounds ( bioactivities). (see details)