Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAST3 (O60307) - Overview - Molecular Target Synopsis

Protein


MAST3, Microtubule-associated serine/threonine-protein kinase 3
Enzyme Classification 2.7.11.1
UniProt O60307

Also Known as MAST3_HUMAN, MAST3, KIAA0561

Interacts with PTEN.

3KHF
THE CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN MICROTUBULE ASSOCIATED SERINE/THREONINE KINASE 3 (MAST3)
RCSB/PDB
Inspect Structure
See all 3D Structures for MAST3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1309ENSG00000099308ENST00000262811ENSP00000262811O60307-1
86ENSG00000099308ENST00000609494ENSP00000477109

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAST3 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_MB_435, HCC_2998, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H446, NCI-H1155, CCRF-SB

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, CD20-positive B cell, NHLF

(see details)

RNA Interference


MAST3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MCF12A, HUO3N1. (see details)

3D Structures


For MAST3 there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MAST3 has been screened with 16 compounds (28 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (2 bioactivities). (see details)