Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADCY3 (O60266) - Overview - Molecular Target Synopsis

Protein


ADCY3, Adenylate cyclase type 3
Enzyme Classification 4.6.1.1
UniProt O60266

Also Known as ADCY3_HUMAN, ADCY3, KIAA0511

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ADCY3 is active in the following subcellular-locations: cell membrane, cell projection, cilium, cytoplasm, golgi apparatus.
GO terms: ADCY3 is active in the following subcellular-locations: cilium, cytoplasm, Golgi apparatus, integral component of membrane, integral component of plasma membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADCY3 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, MDA_MB_231, MDA_MB_435

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-719, HCC4011, G122

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HeLa-S3

(see details)

3D Structures


At greater than 50% identity similarity to ADCY3 there are:
17 structures (34 chains) solved
17 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ADCY3 has been screened with 49 compounds (52 bioactivities), 23 compounds have bioactivities that show binding affinity of <= 500nM (24 bioactivities). (see details)