Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
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Germline Genetics

pfkC (O59355) - Overview - Molecular Target Synopsis

Protein


pfkC, ADP-specific phosphofructokinase
Enzyme Classification 2.7.1.146
UniProt O59355

Also Known as K6PF_PYRHO, pfkC

Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.

3DRW
CRYSTAL STRUCTURE OF A PHOSPHOFRUCTOKINASE FROM PYROCOCCUS HORIKOSHII OT3 WITH AMP
RCSB/PDB
Inspect Structure
See all 3D Structures for pfkC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
450O59355-1

Sub-cellular localization


UniProt: pfkC is active in the following subcellular-locations: cytoplasm.
GO terms: pfkC is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project pfkC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pfkC there are:
2 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

pfkC is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3DRW_A, 3DRW_B).

(see details)
Molecular Target 3D Synopsis