dphB (O58456) - Overview - Molecular Target Synopsis
dphB, Diphthine synthase
Enzyme Classification 126.96.36.199
Also Known as DPHB_PYRHO, dphB, dph5
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. Homodimer.
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