Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Impa1 (O55023) - Overview - Molecular Target Synopsis

Protein


Impa1, Inositol monophosphatase 1
Enzyme Classification 3.1.3.25
UniProt O55023

Also Known as IMPA1_MOUSE, Impa1

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Homodimer.

4AS5
STRUCTURE OF MOUSE INOSITOL MONOPHOSPHATASE 1
RCSB/PDB
Inspect Structure
See all 3D Structures for Impa1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
277O55023-1

Sub-cellular localization


UniProt: Impa1 is active in the following subcellular-locations: cytoplasm.
GO terms: Impa1 is active in the following subcellular-locations: axon, cytoplasm, neuronal cell body.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Impa1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Impa1 there are:
1 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Impa1 has been screened with compounds ( bioactivities). (see details)