Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Crym (O54983) - Overview - Molecular Target Synopsis

Protein


Crym, Ketimine reductase mu-crystallin
Enzyme Classification 1.5.1.25
UniProt O54983

Also Known as CRYM_MOUSE, Crym

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. Homodimer.

4BV8
CRYSTAL STRUCTURE OF THE APO FORM OF MOUSE MU-CRYSTALLIN.
RCSB/PDB
Inspect Structure
See all 3D Structures for Crym

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
313O54983-1

Sub-cellular localization


UniProt: Crym is active in the following subcellular-locations: cytoplasm.
GO terms: Crym is active in the following subcellular-locations: cytoplasm, cytosol, mitochondrion, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Crym has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Crym there are:
3 structures (6 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

Crym is solved in complex with the approved drug(s):

T3/LIOTHYRONINE (4BVA_A, 4BVA_B).

(see details)
Molecular Target 3D Synopsis