Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Cdc42bpa (O54874) - Overview - Molecular Target Synopsis

Protein


Cdc42bpa, Serine/threonine-protein kinase MRCK alpha
Enzyme Classification 2.7.11.1
UniProt O54874

Also Known as MRCKA_RAT, Cdc42bpa, Pk428

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12A and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12C, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Homodimer and homotetramer via the coiled coil regions (PubMed:11283256). Interacts tightly with GTP-bound but not GDP-bound CDC42 (By similarity). Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPA and MYO18A. LURAP1 binding results in activation of CDC42BPA by abolition of its negative autoregulation (PubMed:18854160). Interacts with LURAP1 (PubMed:25107909). Interacts (via AGC-kinase C-terminal domain) with FAM89B/LRAP25 (via LRR repeat) (PubMed:25107909). Forms a tripartite complex with FAM89B/LRAP25 and LIMK1.

4AW2
CRYSTAL STRUCTURE OF CDC42 BINDING PROTEIN KINASE ALPHA (MRCK ALPHA)
RCSB/PDB
Inspect Structure
See all 3D Structures for Cdc42bpa

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1732O54874-1

Sub-cellular localization


UniProt: Cdc42bpa is active in the following subcellular-locations: cell projection, cytoplasm, lamellipodium.
GO terms: Cdc42bpa is active in the following subcellular-locations: actomyosin, cell leading edge, cell-cell junction, cytoplasm, lamellipodium.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Cdc42bpa has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Cdc42bpa there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Cdc42bpa has been screened with compounds ( bioactivities). (see details)