Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

Slc29a1 (O54698) - Overview - Molecular Target Synopsis


Slc29a1, Equilibrative nucleoside transporter 1
UniProt O54698

Also Known as S29A1_RAT, Slc29a1, Ent1

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs). Identified in a complex with STOM.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: Slc29a1 is active in the following subcellular-locations: apical cell membrane, basolateral cell membrane, cell membrane.
GO terms: Slc29a1 is active in the following subcellular-locations: apical plasma membrane, basolateral plasma membrane, integral component of plasma membrane, plasma membrane, postsynapse, presynapse.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project Slc29a1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry

Slc29a1 has been screened with 7 compounds (17 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)