Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Slc29a1 (O54698) - Overview - Molecular Target Synopsis

Protein


Slc29a1, Equilibrative nucleoside transporter 1
UniProt O54698

Also Known as S29A1_RAT, Slc29a1, Ent1

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs). Identified in a complex with STOM.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
457O54698-1

Sub-cellular localization


UniProt: Slc29a1 is active in the following subcellular-locations: apical cell membrane, basolateral cell membrane, cell membrane.
GO terms: Slc29a1 is active in the following subcellular-locations: apical plasma membrane, basolateral plasma membrane, integral component of plasma membrane, plasma membrane, postsynapse, presynapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Slc29a1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry


Slc29a1 has been screened with 7 compounds (17 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)