evaA (O52793) - Overview - Molecular Target Synopsis
evaA, dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Enzyme Classification 220.127.116.11
Also Known as EVAA_AMYOR, evaA, Orf23
Involved in the biosynthesis of the 2,3,6-trideoxysugar L-epivancosamine, the terminal sugar added to the aglycone scaffold of chloroeremomycin, a member of the glycopeptide antibiotics vancomycin family. Catalyzes the removal of the hydroxyl group at position C-2 of the hexose ring of dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose, and the oxidation of the hydroxyl group at position C-3 to form a carbonyl functionality. The product of the reaction, dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose, is a highly unstable diketosugar, which spontaneously forms dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose. Homodimer.
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