Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

evaA (O52793) - Overview - Molecular Target Synopsis

Protein


evaA, dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Enzyme Classification 4.2.1.159
UniProt O52793

Also Known as EVAA_AMYOR, evaA, Orf23

Involved in the biosynthesis of the 2,3,6-trideoxysugar L-epivancosamine, the terminal sugar added to the aglycone scaffold of chloroeremomycin, a member of the glycopeptide antibiotics vancomycin family. Catalyzes the removal of the hydroxyl group at position C-2 of the hexose ring of dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose, and the oxidation of the hydroxyl group at position C-3 to form a carbonyl functionality. The product of the reaction, dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose, is a highly unstable diketosugar, which spontaneously forms dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose. Homodimer.

4J7G
CRYSTAL STRUCTURE OF EVAA, A 2,3-DEHYDRATASE IN COMPLEX WITH DTDP- FUCOSE AND DTDP-RHAMNOSE
RCSB/PDB
Inspect Structure
See all 3D Structures for evaA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Gene Copy Number Variation


In COSMIC - Cell Lines Project evaA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For evaA there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis