Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRKY (O43930) - Overview - Molecular Target Synopsis

Protein


PRKY, Putative serine/threonine-protein kinase PRKY
Enzyme Classification 2.7.11.1
UniProt O43930

Also Known as PRKY_HUMAN, PRKY

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
277O43930-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project PRKY has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, TK_10, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MHH-PREB-1, NCI-H2810, HCC2885

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, HUVEC, SK-N-SH

(see details)

3D Structures


At greater than 50% identity similarity to PRKY there are:
220 structures (250 chains) solved
188 are solved in complex with at least one small molecule ligand
6 are solved with an approved drug

PRKY is solved in complex with the approved drug(s):

A/ADENOSINE PHOSPHATE (1BKX_A),
AMP/ADENOSINE PHOSPHATE (6EH2_A, 6ESA_A),
IPH/PHENOL (3NX8_A),
NCA/NIACINAMIDE (5N3H_A),
ADN/ADENOSINE (1FMO_E).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PRKY has been screened with compounds ( bioactivities). (see details)