BUD23 (O43709) - Overview - Molecular Target Synopsis
BUD23, Probable 18S rRNA (guanine-N(7))-methyltransferase
Enzyme Classification 2.1.1.-
Also Known as BUD23_HUMAN, BUD23, MERM1, WBSCR22
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612). Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492). Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492). Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492). Heterodimer with TRMT112; this heterodimerization is necessary for the metabolic stability and activity of the catalytic subunit BUD23 (PubMed:25851604). Interacts with GRIP1.
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UniProt: BUD23 is active in the following subcellular-locations: cytoplasm, nucleoplasm, nucleus, perinuclear region.
GO terms: BUD23 is active in the following subcellular-locations: nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm.