Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTZ1 (O43708) - Overview - Molecular Target Synopsis

Protein


GSTZ1, Maleylacetoacetate isomerase
Enzyme Classification 5.2.1.2
UniProt O43708

Also Known as MAAI_HUMAN, GSTZ1, MAAI

Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. Homodimer.

1FW1
GLUTATHIONE TRANSFERASE ZETA/MALEYLACETOACETATE ISOMERASE
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTZ1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GSTZ1 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTZ1 is active in the following subcellular-locations: cytosol, mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTZ1 has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_2, MALME_3M, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-157, EVSA-T, NCI-H1581

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, MCF-7, NHLF

(see details)

3D Structures


For GSTZ1 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTZ1 has been screened with 4 compounds (4 bioactivities). (see details)