Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ASNA1 (O43681) - Overview - Molecular Target Synopsis


Enzyme Classification 3.6.-.-
UniProt O43681

Also Known as ASNA_HUMAN, ASNA1, ARSA, TRC40

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling. Homodimer (By similarity). Component of a transmembrane domain recognition complex (TRC) (By similarity). Interacts with SERP1 and SEC61B (By similarity). Interacts with WRB.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
348ENSG00000198356ENST00000591090, ENST00000357332ENSP00000466379, ENSP00000349887O43681-1, A5PJI5-1

Sub-cellular localization

UniProt: ASNA1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum, nucleolus, nucleus.
GO terms: ASNA1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum membrane, extracellular exosome, GET complex, nucleolus, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ASNA1 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: TK_10, SK_MEL_2, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVSAHO, BFTC-905, G84

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HeLa-S3

(see details)

3D Structures

At greater than 50% identity similarity to ASNA1 there are:
4 structures (16 chains) solved
3 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis