Molecular Target Synopsis
Overview
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PRC1 (O43663) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed8
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria7


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4L3I_B Protein regulator of cytokinesis 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.46 72.6 29.7 Yes Yes
2 empty 2.23 77.3 26.4 No No
3 empty .98 50.2 21.2 No No
4 empty 1.62 61.9 19.3 No No
5 empty 2.22 69.4 24.2 No No
6 empty 1.88 73 26.1 No No
7 empty 1.5 67.2 15.2 No No
8 empty 1.4 54.5 15.8 No No
9 empty 1.85 59.9 11.5 No No
10 empty 1.59 79 9.3 No No
3NRX_A Protein regulator of cytokinesis 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 63.5 29.4 Yes No
2 empty 2.02 66.7 17 No No
3 empty 2.15 67.5 21.3 No No
4 empty 2.56 63.7 17.9 No No
5 empty 2.44 69.8 12.9 No No
6 empty 2.49 61.1 11.4 No No
7 empty 2.34 64.6 11.7 No No
8 empty 2.55 65.2 8.7 No No
9 empty 1.58 63.1 10.9 No No
10 empty 1.76 46.2 9.8 No No
4L6Y_A Protein regulator of cytokinesis 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 76.6 25.4 Yes Yes
2 empty 2.35 60.3 29.9 No No
3 empty 1.37 54.3 40.8 No No
4 empty 1.84 64.9 29.6 No No
5 empty 1.74 69.4 30.7 No No
6 empty 2.13 63.2 19.7 No No
7 empty 2.36 75 17 No No
8 empty 1.83 65.2 13.5 No No
9 empty 2.48 74.2 15.8 No No
10 empty 2.38 63.8 13.7 No No
3NRY_A Protein regulator of cytokinesis 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 58.4 23 No No
2 empty 2.18 68.3 15.7 No No
3 empty 1.8 71.8 14.4 No No
4 empty 1.97 69.8 16 No No
5 empty 2.37 78.5 8.8 No No
6 empty 2.35 73 10.4 No No
7 empty 2.45 59 13.8 No No
8 empty 1.83 57.8 12.7 No No
9 empty 2.41 57.8 10.8 No No
10 empty 2.54 60.2 13.6 No No
4L3I_A Protein regulator of cytokinesis 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 72 25.7 Yes Yes
2 empty 1.76 58 23.3 No No
3 empty .44 48.5 22.1 No No
4 empty 2.21 71.1 20.7 No No
5 empty 1.68 67.8 15.9 No No
6 empty 2.14 63.8 19.4 No No
7 empty 2.32 68 13.7 No No
8 empty 1.94 80.6 14.1 No No
9 empty 1.99 71.1 12.9 No No
10 empty 2.07 68.8 8.9 No No
5KMG_P Protein regulator of cytokinesis 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 63.8 24.8 Yes No
2 empty 1.67 60.5 15.9 No No
3 empty 2.45 66 15 No No
4 empty 2.24 61.1 17 No No
5 empty 2.3 59.8 16.2 No No
6 empty 2.34 76.7 9.7 No No
7 empty 2.21 66 13.2 No No
8 empty 2.44 68.8 8 No No
9 empty 2.7 60 7.9 No No
10 empty 2.7 61.9 10.6 No No
3NRX_B Protein regulator of cytokinesis 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 69.2 24.1 Yes No
2 empty 2.22 62 13.7 No No
3 empty 2.27 65.5 16.1 No No
4 empty 2.32 74.3 14.5 No No
5 empty 1.97 48.9 13 No No
6 empty 2.18 62.2 16.6 No No
7 empty 1.99 56.1 10.7 No No
8 empty 2.23 81.8 11.1 No No
9 empty 1.48 63.1 8.6 No No
10 empty 2.35 59.9 8.9 No No
4L6Y_B Protein regulator of cytokinesis 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 71.4 31.5 Yes Yes
2 empty .83 49.7 23 No No
3 empty 2.05 68.1 17 No No
4 empty 1.53 72.1 20.6 No No
5 empty 2.04 64.7 17.8 No No
6 empty 2.01 59 18.8 No No
7 empty 2.29 69.7 19.8 No No
8 empty 1.88 65.6 22 No No
9 empty 2.12 70.4 13.3 No No
10 empty 1.87 60.8 17.1 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3NRX_A (3560982) Protein regulator of cytokinesis 1 UNMATCHED, UNMATCHED, UNMATCHED 3NRX 1.75Å Yes No
3NRY_A (3560983) Protein regulator of cytokinesis 1 EF Hand-like, EF-hand, Calbindin D9K 2Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PRC1 is involved in 14 interactions in the network.


Druggability
Overall Druggability Percentile: 74.54
Druggability for Cancer Therapeutics: 87.70
Druggability for Other Therapeutics: 46.49
Cancer-Associated
Cancer-associated percentile : 90.10
Network Articulation Point
Is PRC1 critical for communication in the network?


Detailed Graph Legend:Help