Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NCK2 (O43639) - Overview - Molecular Target Synopsis

Protein


NCK2, Cytoplasmic protein NCK2
UniProt O43639

Also Known as NCK2_HUMAN, NCK2, GRB4

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Interacts with DOCK1, LIMS1 and TGFB1I1. Part of a complex containing PPP1R15B, PP1 and NCK2. Interacts with FASLG (By similarity). Interacts with AXL. Interacts with PAK1, PKN2 and SOS1. Interacts (via SH2 domain) with EGFR. Interacts (via SH2 domain) with DDR1.

4E6R
CRYSTAL STRUCTURE OF A CYTOPLASMIC PROTEIN NCK2 (NCK2) FROM HOMO SAPIENS AT 2.20 A RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for NCK2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NCK2 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum.
GO terms: NCK2 is active in the following subcellular-locations: cytoplasm, cytosol, endoplasmic reticulum, postsynaptic density, vesicle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NCK2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, UACC_257, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK23, COLO 853, DEOC-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, HMEC, A549

(see details)

3D Structures


For NCK2 there are:
9 structures (10 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NCK2 has been screened with compounds ( bioactivities). (see details)