Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TNFSF12 (O43508) - Overview - Molecular Target Synopsis

Protein


TNFSF12, Tumor necrosis factor ligand superfamily member 12
UniProt O43508

Also Known as TNF12_HUMAN, TNFSF12, APO3L, DR3LG

Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. Homotrimer (Probable). Interacts with the angiogenic factor AGGF1/VG5Q.

4HT1
HUMAN TWEAK IN COMPLEX WITH THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY
RCSB/PDB
Inspect Structure
See all 3D Structures for TNFSF12

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TNFSF12 is active in the following subcellular-locations: cell membrane, secreted.
GO terms: TNFSF12 is active in the following subcellular-locations: extracellular region, extracellular space, integral component of plasma membrane, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TNFSF12 has gain in 1 cell-lines, loss in 6 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, U251, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G28T, Hs 675.T, NCI-H2373

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, NHLF, BJ

(see details)

3D Structures


For TNFSF12 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis