Molecular Target Synopsis
Overview
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Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Gene Copy Number Variation
RNAi
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EEF1E1 (O43324) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed10
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria9


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5BMU_E Eukaryotic translation elongation factor 1 epsilon-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 66 40.4 Yes No
2 empty 2.31 73.5 23 No No
3 empty 1.98 70.3 14.1 No No
4 empty 2.14 62.4 12.2 No No
5 empty 1.91 71.7 12.2 No No
6 empty 2.85 69 14.6 No No
7 empty 1.72 66.5 12.3 No No
8 empty 2.33 59.5 13.8 No No
9 empty 2.16 62.4 8.3 No No
10 empty 2.67 63.9 6.8 No No
2UZ8_B Eukaryotic translation elongation factor 1 epsilon-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 65.7 38.6 Yes No
2 bound 1.95 65.9 20.6 No No
3 empty 2.31 65.7 17.3 No No
4 empty 2.2 61.2 15.4 No No
5 empty 2.02 71.6 12.1 No No
6 empty 2.33 67.3 12.9 No No
7 empty 2.06 60.2 13.3 No No
8 empty 2.62 65.7 9.5 No No
9 empty 1.45 65.5 9.5 No No
10 empty 2.04 84.3 6.9 Yes No
5BMU_C Eukaryotic translation elongation factor 1 epsilon-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.47 68.6 38.8 Yes Yes
2 empty 2.04 70.3 20.2 No No
3 empty 2.49 69.5 16.3 No No
4 empty 2.27 61 15.5 No No
5 empty 1.96 58.1 14.1 No No
6 empty 1.97 72.4 12.8 No No
7 empty 2.26 62.3 15.4 No No
8 empty 2.82 80.5 6.4 No No
9 empty 2.06 72.5 5.5 No No
10 empty 2.68 55.7 9 No No
5Y6L_B Eukaryotic translation elongation factor 1 epsilon-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 68.3 25.7 Yes Yes
2 empty 2.59 61.7 16.5 No No
3 empty 2.14 60.4 14.5 No No
4 empty 1.82 83.1 13.8 No No
5 empty 1.83 71.5 11.1 No No
6 empty 2.43 56.1 21.1 No No
7 empty 2.46 70.7 13.8 No No
8 empty 2.22 60.4 13.4 No No
9 empty 2.43 61.2 11 No No
10 empty 1.84 62.1 9.4 No No
2UZ8_A Eukaryotic translation elongation factor 1 epsilon-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 65.9 34.6 Yes No
2 bound 1.94 68.8 20.5 No No
3 empty 2.6 63.7 24.7 No No
4 empty 2.45 64.4 28.8 No No
5 empty 2.25 62.5 17.5 No No
6 empty 2 74 10.3 No No
7 empty 1.96 62.2 11.7 No No
8 empty 2.58 58.4 14.9 No No
9 empty 2.21 74.2 10 No No
10 empty 2.62 69.5 6.1 No No
4BL7_B Eukaryotic translation elongation factor 1 epsilon-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 63.3 46.4 Yes No
2 empty 1.91 63 18.9 No No
3 empty 2.35 59.4 16 No No
4 empty 2.07 72.4 20.7 No No
5 empty 2.29 62.9 13.7 No No
6 empty 2.38 67 14 No No
7 empty 2.21 63.3 7.7 No No
8 empty 2.38 66.7 8.9 No No
9 empty 2.52 77.3 8.6 No No
10 empty 2.28 64.1 10.3 No No
5BMU_G Eukaryotic translation elongation factor 1 epsilon-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 67.2 36.4 Yes Yes
2 empty 1.8 66.2 17.8 No No
3 empty 2.44 63.1 18.1 No No
4 empty 2.11 70.5 21.2 No No
5 empty 1.85 62.7 12.9 No No
6 empty 1.87 71.3 13.7 No No
7 empty 2.35 66.5 17 No No
8 empty 2.03 70.5 8.8 No No
9 empty 2.38 62.3 11 No No
10 empty 2.11 67.5 10.4 No No
4BVX_B Eukaryotic translation elongation factor 1 epsilon-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 62.9 42.8 Yes No
2 bound 2.32 71.1 22.6 No No
3 empty 2.18 59.6 12.9 No No
4 empty 1.75 73.5 11.4 No No
5 empty 2.28 63.7 13.3 No No
6 empty 2.77 62.8 9.4 No No
7 empty 2.44 74.7 8.6 No No
8 empty 1.89 64.1 8.1 No No
9 empty 2.09 62.4 9.1 No No
10 empty 1.83 77.7 8.8 No No
5BMU_A Eukaryotic translation elongation factor 1 epsilon-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 67 36 Yes Yes
2 empty 1.88 67.4 19.7 No No
3 empty 2.45 65.6 18.3 No No
4 empty 1.91 61.8 13.7 No No
5 empty 2.47 63.3 19.8 No No
6 empty 2.05 70.8 11 No No
7 empty 2.46 60.1 14 No No
8 empty 2.14 59.2 12.9 No No
9 empty 2.59 65 7.4 No No
10 empty 2.62 80.1 9.6 No No
4BVY_B Eukaryotic translation elongation factor 1 epsilon-1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 63.5 23.6 No No
2 empty 2.26 63.8 15.2 No No
3 empty 2.24 66.9 19.5 No No
4 empty 1.88 70.4 11.3 No No
5 empty 2.35 64.6 10.5 No No
6 empty 2.42 63.5 18.7 No No
7 empty 2.11 81.3 13 No No
8 empty 2.28 69 13 No No
9 empty 2.39 66.9 15 No No
10 empty 1.97 73.9 10.7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed1
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria1

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2UZ8_A (3210276) Eukaryotic translation elongation factor 1 epsilon-1 UNMATCHED, UNMATCHED, UNMATCHED 2UZ8 2Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


EEF1E1 is involved in 5 interactions in the network.


Druggability
Overall Druggability Percentile: 40.80
Druggability for Cancer Therapeutics: 38.33
Druggability for Other Therapeutics: 10.74
Cancer-Associated
Cancer-associated percentile : 67.98
Network Articulation Point
Is EEF1E1 critical for communication in the network?


Detailed Graph Legend:Help