Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EEF1E1 (O43324) - Overview - Molecular Target Synopsis

Protein


EEF1E1, Eukaryotic translation elongation factor 1 epsilon-1
UniProt O43324

Also Known as MCA3_HUMAN, EEF1E1, AIMP3, P18

Positive modulator of ATM response to DNA damage. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464). Can interact simultaneously with MARS and EPRS (PubMed:26472928). Forms a linear complex that contains MARS, EEF1E1, EPRS and AIMP2 that is at the core of the multisubunit complex (PubMed:26472928). Interacts with ATM and ATR. The interaction with ATM, which takes place independently of TP53, is induced by DNA damage that may occur during genotoxic stress or cell growth. The interaction with ATR is enhanced by UV irradiation.

5Y6L
A SUBCOMPLEX CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC ASPARTYL-TRNA SYNTHETASE AND HETEROTETRAMERIC GLUTATHIONE TRANSFERASE-HOMOLOGY DOMAINS IN MULTI-TRNA SYNTHETASE COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for EEF1E1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: EEF1E1 is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.
GO terms: EEF1E1 is active in the following subcellular-locations: aminoacyl-tRNA synthetase multienzyme complex, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project EEF1E1 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, HL_60, CCRF_CEM

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MHH-PREB-1, OVCAR-8, OCI-M1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, IMR-90, HeLa-S3

(see details)

3D Structures


For EEF1E1 there are:
6 structures (10 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis