Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PPIP5K2 (O43314) - Overview - Molecular Target Synopsis

Protein


PPIP5K2, Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
Enzyme Classification 2.7.4.21
UniProt O43314

Also Known as VIP2_HUMAN, PPIP5K2, HISPPD1, KIAA0433, VIP2

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.

5DGI
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE 2 (PPIP5K2) IN COMPLEX WITH ADP AND 3,5- (PCP)2-IP4
RCSB/PDB
Inspect Structure
See all 3D Structures for PPIP5K2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PPIP5K2 is active in the following subcellular-locations: cytoplasm, cytosol.
GO terms: PPIP5K2 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PPIP5K2 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TK, SUP-B15, SKM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, GM12878, AG445

(see details)

3D Structures


For PPIP5K2 there are:
19 structures (19 chains) solved
19 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PPIP5K2 has been screened with compounds ( bioactivities). (see details)