ADCY6 (O43306) - Overview - Molecular Target Synopsis
ADCY6, Adenylate cyclase type 6
Enzyme Classification 126.96.36.199
Also Known as ADCY6_HUMAN, ADCY6, KIAA0422
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli. Part of a complex containing AKAP5, ADCY5, PDE4C and PKD2 (By similarity). Interacts with RAF1 (PubMed:15385642). Interacts (via cytoplasmic N-terminus) with GNAS, GNB1 and GNG2 (PubMed:17110384).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|1115||ENSG00000174233||ENST00000357869, ENST00000550422||ENSP00000350536, ENSP00000446730||O43306-2|
UniProt: ADCY6 is active in the following subcellular-locations: cell membrane, cell projection, cilium, stereocilium.
GO terms: ADCY6 is active in the following subcellular-locations: cilium, integral component of plasma membrane, intrinsic component of plasma membrane, membrane, plasma membrane, stereocilium.