Molecular Target Synopsis
Overview
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Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
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Gene Copy Number Variation
RNAi
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Germline Genetics

DAPK3 (O43293) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed14
Chains with at least one site assessed as druggable using the strict criteria9
Chains with at least one site assessed as druggable using the relaxed criteria14


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5VJA_A Death-associated protein kinase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 67.7 45.4 Yes Yes
2 empty 2.39 67.2 30.8 No No
3 empty 2.3 62 23.8 No No
4 empty 2.27 66.5 26.5 No No
5 empty 2.3 60.8 15.2 No No
6 empty 2.42 57.9 20.4 No No
7 empty 2.42 63.7 14.9 No No
8 empty 2.12 68.1 14.3 No No
9 bound 1.51 71.1 10.5 No No
10 empty 2.46 68.2 11.1 No No
1YRP_A Death-associated protein kinase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 70.1 43.6 Yes Yes
2 empty 2.11 63.2 36.3 No No
3 empty 2.28 66.1 28.2 No No
4 empty 2.21 66.2 22.7 No No
5 empty 2.48 63.6 18 No No
6 empty 2.24 54 24 No No
7 empty 2.49 55.5 17.3 No No
8 empty 2.07 65.7 9.9 No No
9 empty 2.51 68.3 8.9 No No
10 empty 2.82 71 7.9 No No
3BQR_A Death-associated protein kinase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.63 64 50.1 Yes No
2 bound 1.99 72.5 46.2 No No
3 empty 2.56 58.7 24.7 No No
4 empty 2.58 59.4 22.3 No No
5 bound 2.3 63.4 25 No No
6 empty 2.4 71 20.2 No No
7 empty 2.24 74.2 9.8 No No
8 empty 2.48 61.9 13.6 No No
9 empty 2.54 74.3 8 No No
10 empty 2.28 65.6 9.3 No No
5A6O_A Death-associated protein kinase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 65.8 46 Yes No
2 bound 2.17 64.7 45.3 No No
3 bound 2.25 66.6 23.8 No No
4 empty 2.26 65.2 27 No No
5 empty 2.54 62.8 14.6 No No
6 empty 2.44 55.5 16.8 No No
7 empty 2.14 55.2 11.9 No No
8 empty 2.24 69.6 9.6 No No
9 empty 1.74 69.7 9.3 No No
10 empty 2.6 62 9.1 No No
2J90_A Death-associated protein kinase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.49 62.1 37.5 Yes No
2 bound 1.85 70.3 41.6 No No
3 empty 2.22 67.7 27.4 No No
4 empty 2.14 64.9 21 No No
5 empty 2.46 63.4 15.6 No No
6 empty 2.28 59.6 13.8 No No
7 empty 2.35 71 11.5 No No
8 empty 1.95 48.6 13.1 No No
9 empty 2.09 59.9 12.5 No No
10 empty 1.94 65.3 11.2 No No
1YRP_B Death-associated protein kinase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 66 44.1 Yes No
2 empty 2.4 61.4 16.7 No No
3 empty 2.31 61.5 19.6 No No
4 empty 2.07 65.9 13.5 No No
5 empty 2.12 54 18.3 No No
6 empty 2.2 50.1 19.8 No No
7 empty 2.17 59.7 15.9 No No
8 bound 2.19 64.4 14.5 No No
9 empty 1.96 60.7 11.5 No No
10 empty 1.63 71.2 11 No No
5VJA_C Death-associated protein kinase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 70.6 42 Yes Yes
2 empty 1.98 68 24.9 No No
3 empty 2.3 63.4 16.3 No No
4 empty 2.5 59.8 15.5 No No
5 empty 2.57 61.4 18.7 No No
6 empty 2.23 66.2 20.4 No No
7 bound 1.53 79.1 10.6 No No
8 empty 2.36 62.9 15.3 No No
9 empty 2.32 54.7 18.3 No No
10 empty 2.06 63.7 13.3 No No
3BHY_A Death-associated protein kinase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 68.3 45.5 Yes Yes
2 empty 2.16 64.2 35.8 No No
3 empty 2.09 68.3 25.8 No No
4 empty 2.35 63.5 21.6 No No
5 empty 2.3 62.5 15.5 No No
6 empty 2.22 62.6 25.9 No No
7 empty 1.75 76.1 13.8 No No
8 empty 2.49 61.8 21.8 No No
9 empty 2.08 71.2 10 No No
10 empty 2.44 74.8 7.8 No No
5A6O_B Death-associated protein kinase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 67.7 47.3 Yes Yes
2 empty 1.6 62.7 41.3 No No
3 bound 2.32 62.5 22.9 No No
4 empty 2.38 61.4 22.8 No No
5 empty 2.41 57 18.1 No No
6 empty 2.38 59 18 No No
7 empty 2.19 69.7 15.7 No No
8 empty 1.99 55.4 12.3 No No
9 empty 2.53 64.9 11.3 No No
10 empty 2.86 60.4 15.2 No No
5VJA_B Death-associated protein kinase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 67.9 45.1 Yes Yes
2 empty 2.3 62.6 24.1 No No
3 empty 2.24 67.3 33.2 No No
4 empty 2.13 72 23.7 No No
5 empty 2.47 64.8 26.5 No No
6 empty 2.44 60 15.9 No No
7 empty 2.64 62 19.7 No No
8 empty 2.43 60.2 20 No No
9 bound 1.58 68.7 10.4 No No
10 empty 2.69 69.5 11.2 No No
5A6N_B Death-associated protein kinase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.66 60 43.1 Yes No
2 bound 1.95 69.4 40.7 No No
3 empty 2.34 61.4 23.8 No No
4 empty 2.2 62.6 24.8 No No
5 empty 2.49 61.5 22.9 No No
6 empty 2.41 59.7 17.8 No No
7 empty 2.28 65.5 22.5 No No
8 empty 2.29 63.7 13.8 No No
9 empty 2.31 62.3 11.7 No No
10 empty 1.68 72.1 8.5 No No
5VJA_D Death-associated protein kinase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 68 42.9 Yes Yes
2 empty 1.94 63.8 23.8 No No
3 empty 2.4 60.7 16.1 No No
4 empty 2.48 58 15.3 No No
5 empty 2.08 65.9 15.5 No No
6 empty 2.02 57.9 16.4 No No
7 empty 2.2 56.3 12.3 No No
8 bound 1.49 73.1 11.1 No No
9 empty 1.96 61.4 11.2 No No
10 empty 2.07 56.8 11.3 No No
2J90_B Death-associated protein kinase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 67.9 48.9 Yes Yes
2 empty 2.22 62.7 24.4 No No
3 empty 2.19 66 24.3 No No
4 empty 2.01 59.8 17.9 No No
5 empty 2.42 59.2 16.2 No No
6 empty 2.16 54 18.1 No No
7 empty 2.42 53.7 14.5 No No
8 empty 1.64 62.5 11.4 No No
9 empty 2.21 63.9 9.1 No No
10 empty 2.02 59.6 11.1 No No
5A6N_A Death-associated protein kinase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 67.9 46.2 Yes Yes
2 bound 2.16 64.1 24.3 No No
3 empty 2.17 54.8 28.2 No No
4 empty 1.93 58.1 19.8 No No
5 empty 1.96 63.8 15.1 No No
6 empty 2.42 58.9 16.1 No No
7 empty 2.18 61.5 16.1 No No
8 empty 2.48 54.5 19.1 No No
9 empty 2.25 65 13 No No
10 empty 2.21 59 18.1 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed6
Domains assessed as druggable using the strict criteria4
Domains assessed as druggable using the relaxed criteria6

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1YRP_A (3030148) Death-associated protein kinase 3 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 3.1Å Yes Yes
1YRP_B (4076042) Death-associated protein kinase 3 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 3.1Å Yes Yes
1YRP_A (4076042) Death-associated protein kinase 3 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 3.1Å Yes Yes
2J90_A (3130191) Death-associated protein kinase 3 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2Å Yes No
2J90_A (4173720) Death-associated protein kinase 3 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2Å Yes Yes
2J90_B (4173720) Death-associated protein kinase 3 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2Å Yes Yes
3BHY_A (3320121) Death-associated protein kinase 3 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.24Å Yes Yes
3BQR_A (3320568) Death-associated protein kinase 3 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.75Å Yes No
Ligand-based Druggability Score: 0.75
Ligand-based Druggability Score Percentile: 88%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


DAPK3 is involved in 24 interactions in the network.


Druggability
Overall Druggability Percentile: 71.58
Druggability for Cancer Therapeutics: 89.00
Druggability for Other Therapeutics: 49.67
Cancer-Associated
Cancer-associated percentile : 90.45
Network Articulation Point
Is DAPK3 critical for communication in the network?


Detailed Graph Legend:Help