Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

HOXC11 (O43248) - Overview - Molecular Target Synopsis


HOXC11, Homeobox protein Hox-C11
UniProt O43248

Also Known as HXC11_HUMAN, HOXC11, HOX3H

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: HOXC11 is active in the following subcellular-locations: nucleus.
GO terms: HOXC11 is active in the following subcellular-locations: cytosol, nucleoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project HOXC11 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: T47D, DU_145, HOP_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RPMI 2650, MDA-MB-453, MHH-ES-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, SK-N-SH, NHLF

(see details)

3D Structures

At greater than 50% identity similarity to HOXC11 there are:
30 structures (48 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

HOXC11 has been screened with compounds ( bioactivities). (see details)