Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXC11 (O43248) - Overview - Molecular Target Synopsis

Protein


HOXC11, Homeobox protein Hox-C11
UniProt O43248

Also Known as HXC11_HUMAN, HOXC11, HOX3H

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
378ENSG00000123388ENST00000243082ENSP00000243082
304ENSG00000123388ENST00000546378ENSP00000446680O43248-1

Sub-cellular localization


UniProt: HOXC11 is active in the following subcellular-locations: nucleus.
GO terms: HOXC11 is active in the following subcellular-locations: cytosol, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXC11 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, DU_145, HOP_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RPMI 2650, MDA-MB-453, MHH-ES-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 50% identity similarity to HOXC11 there are:
30 structures (48 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXC11 has been screened with compounds ( bioactivities). (see details)