Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC7A4 (O43246) - Overview - Molecular Target Synopsis

Protein


SLC7A4, Cationic amino acid transporter 4
UniProt O43246

Also Known as CTR4_HUMAN, SLC7A4

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
635ENSG00000099960ENST00000403586, ENST00000382932ENSP00000384278, ENSP00000372390O43246-1
88ENSG00000099960ENST00000426145ENSP00000408727

Sub-cellular localization


UniProt: SLC7A4 is active in the following subcellular-locations: membrane.
GO terms: SLC7A4 is active in the following subcellular-locations: integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC7A4 has gain in 15 cell-lines, loss in 2 cell-lines and no signal in 987 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, EKVX, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: EKVX, MeWo, COLO 792

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to SLC7A4 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC7A4 is solved in complex with the approved drug(s):

CLR/CHOLESTEROL (6F34_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC7A4 has been screened with compounds ( bioactivities). (see details)