Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC7A4 (O43246) - Overview - Molecular Target Synopsis


SLC7A4, Cationic amino acid transporter 4
UniProt O43246

Also Known as CTR4_HUMAN, SLC7A4

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
635ENSG00000099960ENST00000403586, ENST00000382932ENSP00000384278, ENSP00000372390O43246-1

Sub-cellular localization

UniProt: SLC7A4 is active in the following subcellular-locations: membrane.
GO terms: SLC7A4 is active in the following subcellular-locations: integral component of membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC7A4 has gain in 15 cell-lines, loss in 2 cell-lines and no signal in 987 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MALME_3M, EKVX, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: EKVX, MeWo, COLO 792

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 35% identity similarity to SLC7A4 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC7A4 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

SLC7A4 has been screened with compounds ( bioactivities). (see details)