Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MSH5 (O43196) - Overview - Molecular Target Synopsis

Protein


MSH5, MutS protein homolog 5
UniProt O43196

Also Known as MSH5_HUMAN, MSH5

Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis. Heterooligomer of MSH4 and MSH5. Interacts with HJURP.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: MSH5 is active in the following subcellular-locations: mismatch repair complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MSH5 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, MOLT_4, HOP_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Jurkat, Clone E6-1, K-562, SUM 1315M02

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, GM12878

(see details)