Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MSH5 (O43196) - Overview - Molecular Target Synopsis


MSH5, MutS protein homolog 5
UniProt O43196

Also Known as MSH5_HUMAN, MSH5

Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity). Heterooligomer of MSH4 and MSH5. Interacts with HJURP.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: MSH5 is active in the following subcellular-locations: mismatch repair complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MSH5 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: K_562, MOLT_4, HOP_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Jurkat, Clone E6-1, K-562, SUM 1315M02

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, GM12878

(see details)