CYP26A1 (O43174) - Overview - Molecular Target Synopsis
CYP26A1, Cytochrome P450 26A1
Enzyme Classification 1.14.13.-
Also Known as CP26A_HUMAN, CYP26A1, CYP26, P450RAI1
Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA., Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|428||ENSG00000095596||ENST00000394139, ENST00000371531||ENSP00000377695, ENSP00000360586||O43174-2|
UniProt: CYP26A1 is active in the following subcellular-locations: endoplasmic reticulum membrane, microsome membrane.
GO terms: CYP26A1 is active in the following subcellular-locations: endoplasmic reticulum membrane, organelle membrane.