Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CYP26A1 (O43174) - Overview - Molecular Target Synopsis

Protein


CYP26A1, Cytochrome P450 26A1
Enzyme Classification 1.14.13.-
UniProt O43174

Also Known as CP26A_HUMAN, CYP26A1, CYP26, P450RAI1

Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA., Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
497ENSG00000095596ENST00000224356ENSP00000224356O43174-1
428ENSG00000095596ENST00000394139, ENST00000371531ENSP00000377695, ENSP00000360586O43174-2

Sub-cellular localization


UniProt: CYP26A1 is active in the following subcellular-locations: endoplasmic reticulum membrane, microsome membrane.
GO terms: CYP26A1 is active in the following subcellular-locations: endoplasmic reticulum membrane, organelle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CYP26A1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, MCF7, RPMI_8226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: PA-1, NCI-H522, G112

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH_RA, SK-N-SH, NHLF

(see details)


Screening and Chemistry


CYP26A1 has been screened with 203 compounds (295 bioactivities), 101 compounds have bioactivities that show binding affinity of <= 500nM (134 bioactivities). (see details)