Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

nbs1 (O43070) - Overview - Molecular Target Synopsis

Protein


nbs1, DNA repair and telomere maintenance protein nbs1
UniProt O43070

Also Known as NBS1_SCHPO, nbs1

Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure. Associates with rad32. Forms a multisubunit endonuclease complex, MRN, together with rad32 and rad50.

4FBK
CRYSTAL STRUCTURE OF A COVALENTLY FUSED NBS1-MRE11 COMPLEX WITH ONE MANGANESE ION PER ACTIVE SITE
RCSB/PDB
Inspect Structure
See all 3D Structures for nbs1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
613O43070-1

Sub-cellular localization


UniProt: nbs1 is active in the following subcellular-locations: chromosome, nucleus, telomere.
GO terms: nbs1 is active in the following subcellular-locations: Mre11 complex, nuclear chromosome, nucleus, site of double-strand break.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project nbs1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For nbs1 there are:
7 structures (13 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis