Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

nup120 (O43044) - Overview - Molecular Target Synopsis

Protein


nup120, Nucleoporin nup120
UniProt O43044

Also Known as NU120_SCHPO, nup120

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. Component of the npc107-120 complex which consists of nup85, nup107, nup120, nup131, nup132 and seh1. Interacts with nup107.

4GQ2
S. POMBE NUP120-NUP37 COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for nup120

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1136O43044-1

Sub-cellular localization


UniProt: nup120 is active in the following subcellular-locations: nucleus.
GO terms: nup120 is active in the following subcellular-locations: nuclear envelope, nuclear periphery, nuclear pore, nuclear pore outer ring.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project nup120 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For nup120 there are:
3 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis