Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Mgll (O35678) - Overview - Molecular Target Synopsis

Protein


Mgll, Monoglyceride lipase
Enzyme Classification 3.1.1.23
UniProt O35678

Also Known as MGLL_MOUSE, Mgll

Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:9341166, PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20729846). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. Homodimer.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
303O35678-1
116O35678-2

Sub-cellular localization


UniProt: Mgll is active in the following subcellular-locations: cytoplasm, cytosol, membrane.
GO terms: Mgll is active in the following subcellular-locations: axon, cytosol, extrinsic component of membrane, membrane, nucleoplasm, synapse, varicosity.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Mgll has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry


Mgll has been screened with 86 compounds (101 bioactivities), 31 compounds have bioactivities that show binding affinity of <= 500nM (37 bioactivities). (see details)