Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Efnb3 (O35393) - Overview - Molecular Target Synopsis

Protein


Efnb3, Ephrin-B3
UniProt O35393

Also Known as EFNB3_MOUSE, Efnb3

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. Interacts with GRIP1 and GRIP2.

3D12
CRYSTAL STRUCTURES OF NIPAH VIRUS G ATTACHMENT GLYCOPROTEIN IN COMPLEX WITH ITS RECEPTOR EPHRIN-B3
RCSB/PDB
Inspect Structure
See all 3D Structures for Efnb3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
340O35393-1

Sub-cellular localization


UniProt: Efnb3 is active in the following subcellular-locations: membrane.
GO terms: Efnb3 is active in the following subcellular-locations: glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, integral component of postsynaptic density membrane, integral component of presynaptic membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Efnb3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Efnb3 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis