Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
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pfyP (O34627) - Overview - Molecular Target Synopsis

Protein


pfyP, Blue-light photoreceptor
UniProt O34627

Also Known as PHOT_BACSU, pfyP, ytvA

Exhibits the same spectroscopical features and blue-light induced photochemistry as plants phototropins, with the reversible formation of a blue-shifted photoproduct, assigned to an FMN-cysteine thiol adduct. Although it is a positive regulator in the activation of the environmental signaling branch of the general stress transcription factor sigma-B, its precise role is undetermined. Homodimer.

2MWG
FULL-LENGTH SOLUTION STRUCTURE OF YTVA, A LOV-PHOTORECEPTOR PROTEIN AND REGULATOR OF BACTERIAL STRESS RESPONSE
RCSB/PDB
Inspect Structure
See all 3D Structures for pfyP

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
261O34627-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project pfyP has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pfyP there are:
4 structures (8 chains) solved
4 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

pfyP is solved in complex with the approved drug(s):

FMN/RIBOFLAVIN 5'-PHOSPHATE (2MWG_A, 2MWG_B, 2PR5_A, 2PR5_B, 2PR6_A, 2PR6_B, 4GCZ_A, 4GCZ_B).

(see details)
Molecular Target 3D Synopsis