Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

pucM (O32142) - Overview - Molecular Target Synopsis

Protein


pucM, 5-hydroxyisourate hydrolase
Enzyme Classification 3.5.2.17
UniProt O32142

Also Known as HIUH_BACSU, pucM, yunM

Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). Homotetramer.

2H0E
CRYSTAL STRUCTURE OF PUCM IN THE ABSENCE OF SUBSTRATE
RCSB/PDB
Inspect Structure
See all 3D Structures for pucM

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
114O32142-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project pucM has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pucM there are:
3 structures (6 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis