Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

yncF (O31801) - Overview - Molecular Target Synopsis

Protein


yncF, Probable deoxyuridine 5'-triphosphate nucleotidohydrolase YncF
Enzyme Classification 3.6.1.23
UniProt O31801

Also Known as YNCF_BACSU, yncF

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Homotrimer.

4B0H
B. SUBTILIS DUTPASE YNCF IN COMPLEX WITH DU, PPI AND MG B (P212121)
RCSB/PDB
Inspect Structure
See all 3D Structures for yncF

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
144O31801-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project yncF has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For yncF there are:
6 structures (42 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis