Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

tatAd (O31467) - Overview - Molecular Target Synopsis

Protein


tatAd, Sec-independent protein translocase protein TatAd
UniProt O31467

Also Known as TATAD_BACSU, tatAd, yczB

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. Required for PhoD secretion. The cytosolic fraction of TatAd binds the precursor of PhoD. Forms a complex with TatCd. Two types of complexes exist: one composed of TatAd and TatCd, and another composed only of TatAd. Soluble TatAd forms homomultimers bigger than 100 kDa. Soluble TatAd associates in homomultimeric micelle-like particles with a size of about 12 or 25 nm in diameter as well as in elongated particles of 12 nm in diameter.

2L16
SOLUTION STRUCTURE OF BACILLUS SUBTILITS TATAD PROTEIN IN DPC MICELLES
RCSB/PDB
Inspect Structure
See all 3D Structures for tatAd

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
70O31467-1

Sub-cellular localization


UniProt: tatAd is active in the following subcellular-locations: cell membrane, cytoplasm, cytosol.
GO terms: tatAd is active in the following subcellular-locations: cytosol, integral component of plasma membrane, TAT protein transport complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project tatAd has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For tatAd there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis