Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(O29944) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed1
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria0


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2HSB_A UPF0332 protein AF_0298 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.36 58.4 15.1 No No
2 bound 2.72 55.5 13.8 No No
3 bound 2.23 74.9 10.4 No No
4 empty 2.16 60.2 11.4 No No
5 empty 2.27 70.1 8.9 No No
6 empty 1.82 64.6 11.5 No No
7 bound 2.02 58.4 15.3 No No
8 empty 2.19 73.2 6.9 No No
9 empty 2.2 67.7 10 No No
10 empty 2.88 58.1 9.1 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed1
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria0

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2HSB_A (3110491) UPF0332 protein AF_0298 PFAM, PFAM, PFAM HEPN 1.9Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score