Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

mthK (O27564) - Overview - Molecular Target Synopsis

Protein


mthK, Calcium-gated potassium channel MthK
UniProt O27564

Also Known as MTHK_METTH, mthK

Calcium-gated potassium channel. Homotetramer.

4RO0
CRYSTAL STRUCTURE OF MTHK GATING RING IN A LIGAND-FREE FORM
RCSB/PDB
Inspect Structure
See all 3D Structures for mthK

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
336O27564-1
230O27564-2

Sub-cellular localization


UniProt: mthK is active in the following subcellular-locations: cell membrane.
GO terms: mthK is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project mthK has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For mthK there are:
24 structures (110 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis