Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CAO (O22265) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed11
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria7


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3DEO_A Signal recognition particle 43 kDa protein, chloroplastic Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 64.3 29 Yes No
2 empty 2.31 64 20.6 No No
3 empty 2.31 58.9 30.4 No No
4 empty 2.33 63.9 21.6 No No
5 empty 1.91 57.7 15.2 No No
6 empty 1.94 61.5 14.2 No No
7 empty 2.36 58 20.4 No No
8 empty 2.46 51.6 15.1 No No
9 empty 2.38 58 11.6 No No
10 empty 2.58 50.9 8.6 No No
5E4W_D Signal recognition particle 43 kDa protein, chloroplastic Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 60 25.1 Yes No
2 empty 2.39 56.1 23 No No
3 empty 1.97 55.5 21.8 No No
4 empty 1.68 50.8 15 No No
5 bound 2.19 63.2 14.2 No No
6 empty 2.22 64.3 9.5 No No
7 empty 2.7 56.1 9.2 No No
8 empty 2.55 70.6 8.3 No No
9 empty 2.17 58.8 7.4 No No
10 empty 2.17 32.6 7.6 No No
2N88_A Signal recognition particle 43 kDa protein, chloroplastic No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 56.4 20.3 No No
2 empty 2.43 54.8 18.8 No No
3 empty 2.43 58.6 9.8 No No
4 empty 2.82 60.4 10.5 No No
5 empty 2.41 57.8 7.6 No No
6 empty 3.22 59.6 7 No No
7 empty 2.79 65.7 7.3 No No
8 empty 2.5 56.8 8.1 No No
9 empty 2.94 77.5 0 No No
10 empty 2.65 42.2 5.8 No No
1X32_A Signal recognition particle 43 kDa protein, chloroplastic Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 60.8 15.2 No No
2 empty 2.73 57 10.7 No No
3 empty 2.24 49.4 10.7 No No
4 empty 2.64 63.2 11.3 No No
5 empty 2.34 69.7 7.8 No No
6 empty 2.48 73.9 7 No No
7 empty 3.11 98.1 0 Yes No
8 empty 3.33 64.6 4.6 No No
9 empty 2.48 73.1 0 No No
1X3P_A Signal recognition particle 43 kDa protein, chloroplastic No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 67.2 14.3 No No
2 empty 2.68 64 11.3 No No
3 empty 2.79 68.3 7.9 No No
4 empty 2.25 64.1 8.2 No No
5 empty 2.35 60.2 7.7 No No
6 empty 2.93 62.4 5.5 No No
3UI2_A Signal recognition particle 43 kDa protein, chloroplastic Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 60.2 35.3 Yes No
2 empty 2.22 66.7 32 No No
3 empty 2.41 57.5 29.7 No No
4 empty 2.17 61.4 25 No No
5 empty 2.02 61.9 14.7 No No
6 empty 1.55 59.9 12.6 No No
7 empty 2.24 74.7 8.8 No No
8 empty 2.58 52.1 13.6 No No
9 empty 2.52 62.2 8.3 No No
10 empty 1.78 54.3 9.5 No No
3DEP_A Signal recognition particle 43 kDa protein, chloroplastic Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 63.1 26 Yes No
2 empty 2.23 61.8 28.7 No No
3 empty 2.44 60.8 34.2 No No
4 empty 2.16 65.4 21.9 No No
5 empty 2.56 66.4 15.6 No No
6 empty 2.12 52.7 13.9 No No
7 empty 2.18 57.9 12.4 No No
8 empty 1.87 59.4 8.6 No No
9 empty 1.97 61.3 7.9 No No
10 empty 2.52 62.3 7.5 No No
5E4X_A Signal recognition particle 43 kDa protein, chloroplastic Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 59.1 25.3 Yes No
2 empty 2.05 55.3 13.6 No No
3 empty 3.07 66.5 9.6 No No
4 empty 1.6 56.6 8.5 No No
5 empty 2.51 56.7 6.5 No No
6 empty 2.37 51.6 6.9 No No
1X3Q_A Signal recognition particle 43 kDa protein, chloroplastic No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 62.3 15.5 No No
2 empty 2.5 60.9 20.4 No No
3 empty 2 60.4 16.6 No No
4 empty 2.24 63.9 9.9 No No
5 empty 2.07 58.1 8.9 No No
6 empty 2.83 65.6 8.7 No No
7 empty 2.9 57.7 9.2 No No
8 empty 2.08 56.4 8.4 No No
9 empty 2.84 52.2 6.2 No No
10 empty 3.09 63.5 6.1 No No
2HUG_A Signal recognition particle 43 kDa protein, chloroplastic No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 62.7 18.9 No No
2 empty 2.45 54.8 17.3 No No
3 empty 2.68 61.4 10.7 No No
4 empty 2.18 64.1 9 No No
5 empty 2.2 51.3 10.7 No No
6 empty 2.97 72.4 6.3 No No
7 empty 2.11 58.6 7.1 No No
8 empty 2.76 60.4 7 No No
9 empty 1.87 48.8 7.9 No No
10 empty 3.08 62.9 7.2 No No
5E4W_C Signal recognition particle 43 kDa protein, chloroplastic Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 62.1 28.4 Yes No
2 empty 2.12 60.3 21.3 No No
3 empty 1.94 59.2 13.9 No No
4 empty 2.7 66.2 9 No No
5 empty 2.4 71.2 13.1 No No
6 empty 2.41 64.6 9.9 No No
7 empty 2.46 59.4 10.6 No No
8 empty 2.45 67 9.1 No No
9 empty 2.71 51.9 7.5 No No
10 empty 2.42 60.3 7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed8
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria0

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1X32_A (121654) Signal recognition particle 43 kDa protein, chloroplastic SH3-like barrel, Chromo domain-like, Chromo domain No No
1X3P_A (121668) Signal recognition particle 43 kDa protein, chloroplastic SH3-like barrel, Chromo domain-like, Chromo domain No No
1X3Q_A (121669) Signal recognition particle 43 kDa protein, chloroplastic SH3-like barrel, Chromo domain-like, Chromo domain No No
2HUG_A (147404) Signal recognition particle 43 kDa protein, chloroplastic SH3-like barrel, Chromo domain-like, Chromo domain No No
3DEO_A (157592) Signal recognition particle 43 kDa protein, chloroplastic SH3-like barrel, Chromo domain-like, Chromo domain 1.5Å No No
3DEO_A (157593) Signal recognition particle 43 kDa protein, chloroplastic Artificial ankyrin repeat proteins, Artificial ankyrin repeat proteins, Artificial ankyrin repeat proteins 1.5Å No No
3DEP_A (157594) Signal recognition particle 43 kDa protein, chloroplastic SH3-like barrel, Chromo domain-like, Chromo domain 2.7Å No No
3DEP_A (157595) Signal recognition particle 43 kDa protein, chloroplastic Artificial ankyrin repeat proteins, Artificial ankyrin repeat proteins, Artificial ankyrin repeat proteins 2.7Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score