Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CAO (O22265) - Overview - Molecular Target Synopsis

Protein


CAO, Signal recognition particle 43 kDa protein, chloroplastic
UniProt O22265

Also Known as SR43C_ARATH, CAO, CPSRP43

Component of the chloroplast signal recognition particle pathway. Required for post-translational targeting of proteins into the thylakoid membrane but seems to be dispensable for co-translational targeting with a translating ribosome present. May be able to function independently of cpFTSY and FFC/cpSRP54 in targeting LHCPs to the thylakoids. Acts as a highly specific chaperone for LHCPs, preventing aggregation and being able to dissolve aggregates. Homodimer. Component of the cpSRP complex, composed of a FFC/cpSRP54 monomer and a CAO/cpSRP43 dimer. Interacts (via chromo domains 2 and 3) with ALB3 (via C-terminus), but not with ALB3L1/ALB4. Can interact simultaneously with ALB3 and FFC/cpSRP54. Interacts with LHCP and LTD.

2N88
CHROMODOMAIN 3 (CD3) OF CPSRP43
RCSB/PDB
Inspect Structure
See all 3D Structures for CAO

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
373O22265-1

Sub-cellular localization


UniProt: CAO is active in the following subcellular-locations: chloroplast stroma, plastid.
GO terms: CAO is active in the following subcellular-locations: chloroplast, chloroplast envelope, chloroplast stroma, chloroplast thylakoid membrane, protein-containing complex, signal recognition particle, signal recognition particle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CAO has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For CAO there are:
10 structures (11 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis