Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SUCLG1 (O19069) - Overview - Molecular Target Synopsis

Protein


SUCLG1, Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Enzyme Classification 6.2.1.4
UniProt O19069

Also Known as SUCA_PIG, SUCLG1

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).

5CAE
SUCCINATE BOUND TO PIG GTP-SPECIFIC SUCCINYL-COA SYNTHETASE
RCSB/PDB
Inspect Structure
See all 3D Structures for SUCLG1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
363O19069-1
346O19069-1

Sub-cellular localization


UniProt: SUCLG1 is active in the following subcellular-locations: mitochondrion.
GO terms: SUCLG1 is active in the following subcellular-locations: cytosol, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SUCLG1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For SUCLG1 there are:
8 structures (8 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis