Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(O16025) - Overview - Molecular Target Synopsis

Protein


, Allene oxide synthase-lipoxygenase protein
Enzyme Classification 4.2.1.92
UniProt O16025

Also Known as AOSL_PLEHO

Bifunctional enzyme which is responsible for allene oxide biosynthesis via a two-step reaction which involves conversion of arachidonic acid to a 8R-hydroperoxide intermediate followed by conversion of the hydroperoxide to allene oxide. Dimer.

4QWT
ANAEROBIC CRYSTAL STRUCTURE OF DELTA413-417:GS LOX IN COMPLEX WITH ARACHIDONATE
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1066O16025-1

Sub-cellular localization


UniProt: is active in the following subcellular-locations: cytoplasm, membrane.
GO terms: is active in the following subcellular-locations: cytoplasm, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
7 structures (22 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


has been screened with compounds ( bioactivities). (see details)