Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FABP7 (O15540) - Overview - Molecular Target Synopsis

Protein


FABP7, Fatty acid-binding protein, brain
UniProt O15540

Also Known as FABP7_HUMAN, FABP7, BLBP, FABPB, MRG

B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers.

5URA
ENANTIOMER-SPECIFIC BINDING OF THE POTENT ANTINOCICEPTIVE AGENT SBFI- 26 TO ANANDAMIDE TRANSPORTERS FABP7
RCSB/PDB
Inspect Structure
See all 3D Structures for FABP7

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
166ENSG00000164434ENST00000356535ENSP00000348931O15540-2
132ENSG00000164434ENST00000368444ENSP00000357429O15540-1

Sub-cellular localization


UniProt: FABP7 is active in the following subcellular-locations: cytoplasm.
GO terms: FABP7 is active in the following subcellular-locations: cell periphery, cell projection, cell-cell junction, cytosol, neuronal cell body, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FABP7 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_19, UACC_62, U251

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H187, HCC2688, SK-MEL-24

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For FABP7 there are:
4 structures (8 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FABP7 has been screened with compounds ( bioactivities). (see details)