Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TLR3 (O15455) - Overview - Molecular Target Synopsis

Protein


TLR3, Toll-like receptor 3
UniProt O15455

Also Known as TLR3_HUMAN, TLR3

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. Monomer and homodimer; dimerization is triggered by ligand-binding, the signaling unit is composed of one ds-RNA of around 40 bp and two TLR3 molecules, and lateral clustering of signaling units along the length of the ds-RNA ligand is required for TLR3 signal transduction. Interacts (via transmembrane domain) with UNC93B1; the interaction is required for transport from the ER to the endosomes. Interacts with SRC; upon binding of double-stranded RNA. Interacts with TICAM1 (via the TIR domain) in response to poly(I:C) and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436). The tyrosine-phosphorylated form (via TIR domain) interacts with WDFY1 (via WD repeat 2) in response to poly(I:C) (PubMed:25736436).

5GS0
CRYSTAL STRUCTURE OF THE COMPLEX OF TLR3 AND BI-SPECIFIC DIABODY
RCSB/PDB
Inspect Structure
See all 3D Structures for TLR3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TLR3 is active in the following subcellular-locations: early endosome, endoplasmic reticulum membrane, endosome membrane.
GO terms: TLR3 is active in the following subcellular-locations: cytoplasm, early endosome, endolysosome membrane, endoplasmic reticulum membrane, endosome membrane, extracellular matrix, extracellular space, Golgi membrane, integral component of plasma membrane, intracellular, lysosomal membrane, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TLR3 has gain in 0 cell-lines, loss in 15 cell-lines and no signal in 988 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, A498, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Capan-2, HCC1319, HCC1011

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, A549

(see details)

RNA Interference


TLR3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For TLR3 there are:
7 structures (11 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TLR3 has been screened with 110 compounds (114 bioactivities). (see details)