Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCC4 (O15439) - Overview - Molecular Target Synopsis

Protein


ABCC4, Multidrug resistance-associated protein 4
UniProt O15439

Also Known as MRP4_HUMAN, ABCC4, MRP4

May be an organic anion pump relevant to cellular detoxification. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCC4 is active in the following subcellular-locations: membrane.
GO terms: ABCC4 is active in the following subcellular-locations: basolateral plasma membrane, integral component of membrane, membrane, plasma membrane, platelet dense granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCC4 has gain in 7 cell-lines, loss in 6 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, A498, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, OCI-M1, Hs 675.T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: AG445, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to ABCC4 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCC4 has been screened with 88 compounds (147 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)