Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

ABCC3 (O15438) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 5TGK_A 36.32 3.0E-12 1.91Å DTP 2018-05-09
ABC transporter (100%) (view alignment) Cftr (P26361) - MOUSE 3SI7_C 36.49 2.0E-37 2.25Å ATP 2012-02-01
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 5TFJ_A 36.32 3.0E-12 1.85Å DCP 2018-05-09
ABC transporter (100%) (view alignment) (Q9WYC4) - 4Q7L_B 38.4 4.0E-22 2.35Å - 2015-05-20
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1Q3H_A 36.97 9.0E-11 2.5Å ANP 2003-12-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 5TFC_A 36.32 3.0E-12 1.92Å GTP 2018-05-09
ABC transporter (100%) (view alignment) (A0A0E1SLC7) - 5EUM_B 37.29 2.0E-21 1.8Å MLZ 2015-12-02
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0Z_D 36.97 9.0E-11 2.35Å ATP 2003-12-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 2BBO_A 36.54 9.0E-38 2.55Å ATP 2005-11-01
ABC transporter (100%) (view alignment) Cftr (P26361) - MOUSE 3SI7_B 36.49 2.0E-37 2.25Å ATP 2012-02-01
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 2BBS_B 38.58 8.0E-12 2.05Å ATP 2005-11-01
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 5TFB_A 36.32 3.0E-12 1.87Å MGP 2018-05-09
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1XF9_A 36.49 4.0E-11 2.7Å ATP 2004-12-28
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1XFA_A 36.49 6.0E-11 3.1Å ATP 2004-12-28
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 2BBS_A 38.58 8.0E-12 2.05Å ATP 2005-11-01
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 1XMI_A 37.5 5.0E-12 1.9Å ATP 2004-11-09
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0W_C 36.97 9.0E-11 2.2Å - 2003-12-09
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0X_C 36.97 9.0E-11 2.2Å ATP 2003-12-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 2BBT_B 38.58 7.0E-12 2.3Å ATP 2005-11-01
ABC transporter (100%) (view alignment) (Q9WYC4) - 4Q7L_C 38.4 4.0E-22 2.35Å - 2015-05-20
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0W_D 36.97 9.0E-11 2.2Å - 2003-12-09
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0W_A 36.97 9.0E-11 2.2Å - 2003-12-09
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0Z_A 36.97 9.0E-11 2.35Å ATP 2003-12-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 2PZE_A 36.32 3.0E-12 1.7Å ATP 2007-10-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 1XMI_B 37.5 5.0E-12 1.9Å ATP 2004-11-09
ABC transporter (100%) (view alignment) Cftr (P26361) - MOUSE 3SI7_A 36.49 2.0E-37 2.25Å ATP 2012-02-01
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 4WZ6_A 38.58 8.0E-12 2.05Å ATP 2015-11-11
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0Y_D 36.97 9.0E-11 2.55Å ADP 2003-12-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 5TFD_A 36.32 3.0E-12 1.89Å CTP 2018-05-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 5TFI_A 36.32 3.0E-12 1.89Å DGT 2018-05-09
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1XF9_D 36.49 4.0E-11 2.7Å ATP 2004-12-28
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0Z_C 36.97 9.0E-11 2.35Å ATP 2003-12-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 2PZF_A 35.87 1.0E-11 2Å ATP 2007-10-09
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1XF9_B 36.49 4.0E-11 2.7Å ATP 2004-12-28
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0Y_C 36.97 9.0E-11 2.55Å ADP 2003-12-09
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GJU_A 39.42 1.0E-13 2.6Å - 2019-06-26
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GKD_A 36.32 3.0E-12 2.99Å SWE ATP 2019-06-19
ABC transporter (100%) (view alignment) malK (P68187), CFTR (P13569) - HUMAN,BACTERIA 3GD7_C 36.16 3.0E-41 2.7Å B44 2010-03-02
ABC transporter (100%) (view alignment) ABCC1 (P33527) - HUMAN 2CBZ_A 66.67 7.0E-12 1.5Å ATP 2006-05-17
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1XFA_B 36.49 6.0E-11 3.1Å ATP 2004-12-28
ABC transporter (100%) (view alignment) (Q9WYC4) - 4Q7M_B 38.4 4.0E-22 2.3Å - 2015-05-20
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0Z_B 36.97 9.0E-11 2.35Å ATP 2003-12-09
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GJQ_C 39.42 1.0E-13 2.49Å ATP 2019-06-19
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 2BBT_A 38.58 7.0E-12 2.3Å ATP 2005-11-01
ABC transporter (100%) (view alignment) ABCC6 (O95255) - HUMAN 6BZR_A 56.8 8.0E-11 2.8Å ADP 2019-01-23
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 5TFF_A 36.32 3.0E-12 1.89Å UTP 2018-05-09
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GKD_I 36.32 3.0E-12 2.99Å SWE ATP 2019-06-19
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GJS_A 36.32 3.0E-12 1.95Å ATP 2019-06-26
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 1XMI_C 37.5 5.0E-12 1.9Å ATP 2004-11-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 2PZG_B 35.98 4.0E-12 1.8Å ATP 2007-10-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 5TF7_A 36.32 3.0E-12 1.93Å ATP 2018-05-09
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GKD_F 36.32 3.0E-12 2.99Å SWE ATP 2019-06-19
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GKD_L 36.32 3.0E-12 2.99Å ATP 2019-06-19
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0X_D 36.97 9.0E-11 2.2Å ATP 2003-12-09
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GK4_D 36.32 3.0E-12 2.91Å ATP 2019-06-19
ABC transporter (100%) (view alignment) ABCC6 (O95255) - HUMAN 6BZS_A 59.19 3.0E-12 2.3Å - 2018-09-05
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GJQ_G 39.42 1.0E-13 2.49Å ATP 2019-06-19
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R10_B 36.97 9.0E-11 3Å ATP 2003-12-09
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1Q3H_D 36.97 9.0E-11 2.5Å ANP 2003-12-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 1XMI_E 37.5 5.0E-12 1.9Å ATP 2004-11-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 2PZG_A 35.98 4.0E-12 1.8Å ATP 2007-10-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 5TF8_A 36.32 3.0E-12 1.86Å TTP 2018-05-09
ABC transporter (100%) (view alignment) (A0A0E1SLC7) - 5EUM_A 37.29 2.0E-21 1.8Å MLZ 2015-12-02
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 2PZE_B 36.32 3.0E-12 1.7Å ATP 2007-10-09
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GJQ_E 39.42 1.0E-13 2.49Å ATP 2019-06-19
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0X_B 36.97 9.0E-11 2.2Å ATP 2003-12-09
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1Q3H_C 36.97 9.0E-11 2.5Å ANP 2003-12-09
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GK4_A 36.32 3.0E-12 2.91Å ATP 2019-06-19
ABC transporter (100%) (view alignment) ABCC6 (O95255) - HUMAN 6BZR_B 56.8 8.0E-11 2.8Å ADP 2019-01-23
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 5TFA_A 36.32 3.0E-12 1.87Å DUT 2018-05-09
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0W_B 36.97 9.0E-11 2.2Å - 2003-12-09
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GJQ_A 39.42 1.0E-13 2.49Å ATP 2019-06-19
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 1XMI_D 37.5 5.0E-12 1.9Å ATP 2004-11-09
ABC transporter (100%) (view alignment) malK (P68187), CFTR (P13569) - HUMAN,BACTERIA 3GD7_B 36.16 3.0E-41 2.7Å B44 2010-03-02
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1XF9_C 36.49 4.0E-11 2.7Å ATP 2004-12-28
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0X_A 36.97 9.0E-11 2.2Å ATP 2003-12-09
ABC transporter (100%) (view alignment) ABCC1 (P33527) - HUMAN 4C3Z_A 62.45 1.0E-11 2.1Å - 2014-09-10
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GKD_O 36.32 3.0E-12 2.99Å SWE ATP 2019-06-19
ABC transporter (100%) (view alignment) (Q9WYC4) - 4Q7L_A 38.4 4.0E-22 2.35Å - 2015-05-20
ABC transporter (100%) (view alignment) malK (P68187), CFTR (P13569) - HUMAN,BACTERIA 3GD7_D 36.16 3.0E-41 2.7Å B44 2010-03-02
ABC transporter transmembrane region (100%), ABC transporter (100%) (view alignment) ABCC1 (Q8HXQ5) - BOVINE 6BHU_A 57.12 0 3.14Å CLR ATP 2017-12-27
ABC transporter transmembrane region (100%), ABC transporter (100%) (view alignment) ABCC1 (Q8HXQ5) - BOVINE 5UJA_A 57.54 0 3.34Å LTX 2017-02-22
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 2PZF_B 35.87 1.0E-11 2Å ATP 2007-10-09
ABC transporter transmembrane region (100%), ABC transporter (100%) (view alignment) ABCC1 (Q8HXQ5) - BOVINE 5UJ9_A 57.54 0 3.49Å - 2017-02-22
ABC transporter (100%) (view alignment) Cftr (P26361) - MOUSE 3SI7_D 36.49 2.0E-37 2.25Å ATP 2012-02-01
ABC transporter (100%) (view alignment) malK (P68187), CFTR (P13569) - HUMAN,BACTERIA 3GD7_A 36.16 3.0E-41 2.7Å B44 2010-03-02
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0Y_B 36.97 9.0E-11 2.55Å ADP 2003-12-09
ABC transporter (100%) (view alignment) CFTR (P13569) - HUMAN 5TFG_A 36.32 3.0E-12 1.91Å M5T 2018-05-09
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1Q3H_B 36.97 9.0E-11 2.5Å ANP 2003-12-09
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R0Y_A 36.97 9.0E-11 2.55Å ADP 2003-12-09
ABC transporter (100%) (view alignment) (Q20BJ8) - HUMAN 6GKD_R 36.32 3.0E-12 2.99Å SWE ATP 2019-06-19
ABC transporter (100%) (view alignment) Cftr (P26361) - HOUSE MOUSE 1R10_A 36.97 9.0E-11 3Å ATP 2003-12-09
ABC transporter (100%) (view alignment) - 5IDV_A 36.97 3.0E-24 1.45Å - 2016-03-02